Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31634959 | 1.00 | PLK1 (0.60) | PLK1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL16491018 | 0.90 | PLK1 (0.68) | PLK1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL9701615 | 0.84 | KMT2A (0.59) | PLK1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL29318285 | 0.83 | PLK1 (0.60) | PLK1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL19988556 | 0.82 | HDAC8 (0.52) | PLK1KMT2ASMN1; SMN2LMNABRD4 | |
| SCHEMBL16350551 | 0.82 | HDAC8 (0.52) | PLK1KMT2ASMN1; SMN2LMNABRD4 | |
| SCHEMBL22946249 | 0.79 | PARP10 (0.58) | KMT2AMEN1SMN1; SMN2LMNACREBBP | |
| SCHEMBL20239499 | 0.77 | KMT2A (0.54) | KMT2AMEN1SMN1; SMN2LMNACREBBP | |
| SCHEMBL9525522 | 0.77 | CA5A (0.57) | KMT2AMEN1SMN1; SMN2LMNACREBBP | |
| SCHEMBL23484215 | 0.77 | CA5A (0.52) | PLK1KMT2AMEN1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4008405-A1 | UREA COMPOUND FOR ANTAGONIZING LPA1 RECEPTOR | Taisho Pharmaceutical Co., Ltd. (JP) | 2022-06-08 | — | — | EP | disclosed |
| CN-114206832-A | Urea compounds antagonizing LPA1 receptor | 大正制药株式会社 | 2022-03-18 | — | — | CN | disclosed |
| WO-2021020429-A1 | UREA COMPOUND FOR ANTAGONIZING LPA1 RECEPTOR | 大正製薬株式会社 | 2021-02-04 | — | — | WO | disclosed |