Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22949634 | 0.97 | ADORA3 (0.38) | ADORA2AADORA1ADORA3ADORA2BTSHR | |
| SCHEMBL22947637 | 0.97 | ADORA3 (0.38) | ADORA2AADORA1ADORA3ADORA2BTSHR | |
| SCHEMBL22948448 | 0.96 | TSHR (0.37) | ADORA2AADORA1ADORA3ADORA2BTSHR | |
| SCHEMBL22947426 | 0.94 | ADORA2A (0.38) | ADORA2AADORA1ADORA3ADORA2BTSHR | |
| SCHEMBL22947375 | 0.93 | SMN1; SMN2 (0.40) | ADORA2AADORA1ADORA3ADORA2BTSHR | |
| SCHEMBL22948675 | 0.93 | MEN1 (0.36) | ADORA2AADORA1ADORA3ADORA2BTSHR | |
| SCHEMBL22948595 | 0.93 | ADORA2A (0.35) | ADORA2AADORA1ADORA3ADORA2BTSHR | |
| SCHEMBL22947349 | 0.93 | ADORA2A (0.35) | ADORA2AADORA1ADORA3ADORA2BTSHR | |
| SCHEMBL22947525 | 0.92 | ADORA3 (0.39) | ADORA2AADORA1ADORA3ADORA2BTSHR | |
| SCHEMBL22947671 | 0.91 | ADORA3 (0.38) | ADORA2AADORA1ADORA3ADORA2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210036245-A1 | HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2021-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210036245-A1 | HETEROAROMATIC COMPOUNDS | ETV6, FES, LEF1 | ADORA2A 4133/4885ADORA1 4602/4885ADORA3 4118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.