Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.35 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6121949 | 0.84 | CETP (0.34) | MBOAT4RXRARXRBRXRGTSHR | |
| SCHEMBL2239493 | 0.82 | CYP4F2 (0.39) | TTRMBOAT4RXRARXRBRXRG | |
| SCHEMBL12828088 | 0.82 | SIGMAR1 (0.43) | MBOAT4ALDH1A1TSHRSIGMAR1KCNH2 | |
| SCHEMBL9824390 | 0.80 | EPHX1 (0.45) | TTREPHX1KDM4AKDM5A | |
| SCHEMBL10984090 | 0.80 | KCNN4 (0.42) | TTRSIGMAR1KCNH2TMEM97 | |
| SCHEMBL16822169 | 0.79 | KDM4E (0.46) | ALDH1A1TSHRSIGMAR1KCNH2TMEM97 | |
| SCHEMBL15897808 | 0.78 | PTPRC (0.42) | MBOAT4RXRARXRBRXRGKCNH2 | |
| SCHEMBL22664318 | 0.78 | GABRA1 (0.38) | TTRMBOAT4SIGMAR1KCNH2TMEM97 | |
| SCHEMBL2713113 | 0.77 | TTR (0.51) | TTRALDH1A1 | |
| SCHEMBL7472716 | 0.77 | GAA (0.46) | RXRARXRBRXRGALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103063-A1 | THERAPEUTIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-08-25 | — | — | WO | disclosed |