Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | AR | P10275 | 3/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942 | 1.00 | PGR (1.00) | PGRARCHRM1LMNANR3C1 | |
| SCHEMBL5020044 | 1.00 | PGR (1.00) | PGRARCHRM1LMNANR3C1 | |
| SCHEMBL16690685 | 1.00 | PGR (1.00) | PGRARCHRM1LMNANR3C1 | |
| Acetic Acid SCHEMBL25192781 | 0.98 | PGR (0.96) | PGRARCHRM1LMNANR3C1 | |
| Acetic Acid SCHEMBL28104035 | 0.97 | PGR (0.94) | PGRARCHRM1LMNANR3C1 | |
| Ethylene Glycol SCHEMBL28094936 | 0.96 | PGR (0.92) | PGRARCHRM1LMNANR3C1 | |
| SCHEMBL6690848 | 0.91 | PGR (0.83) | PGRARCHRM1LMNANR3C1 | |
| SCHEMBL6695320 | 0.90 | PGR (0.82) | PGRARCHRM1LMNANR3C1 | |
| Mechlorethamine SCHEMBL28097486 | 0.89 | PGR (0.79) | PGRARCHRM1LMNANR3C1 | |
| SCHEMBL11303204 | 0.88 | PGR (0.79) | PGRARCHRM1LMNANR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9295682-B2 | Adjuvant immunotherapy for the preventive, curative or palliative treatment of chronic systemic diseases such as cancer, of clinical manifestations associated with diseases like cachexia and correction of adverse effects of drugs such as immunosuppression, neutropenia and lymphopenia, comprising the association or combination of a biological response modifier specially selected and other substances with antineoplastic action and/or other treatments | NUNES ISEU DA SILVA (BR) | 2016-03-29 | — | — | US | disclosed |
| WO-2011082458-A1 | ADJUVANT IMMUNOTHERAPY FOR THE PREVENTIVE, CURATIVE OR PALLIATIVE TREATMENT OF CHRONIC SYSTEMIC DISEASES SUCH AS CANCER, OF CLINICAL MANIFESTATIONS ASSOCIATED WITH THESE DISEASES, SUCH AS CACHEXIA, AND REMEDYING ADVERSE EFFECTS OF DRUGS AND TREATMENTS, SUCH AS IMMUNODEPRESSION, NEUTROPENIA AND LYMPHOCYTOPENIA, COMPRISING THE ASSOCIATION OR COMBINATION OF A SPECIALLY SELECTED BIOLOGICAL RESPONSE MODIFIER AND OTHER ANTINEOPLASTIC COMPOUNDS AND/OR OTHER TREATMENTS | NUNES LSEU DA SILVA (BR) | 2011-07-14 | — | — | WO | disclosed |