Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | PDE5A | O76074 | 7/20 | 0.57 |
| ▸ | GBA1 | P04062 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.49 |
| ▸ | USP2 | O75604 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298056 | 0.88 | MEN1 (0.72) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL2297695 | 0.85 | USP1 (0.61) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL2303236 | 0.85 | MEN1 (0.61) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL2291454 | 0.82 | LMNA (0.66) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL2233800 | 0.82 | MEN1 (0.66) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL13929494 | 0.80 | RAD52 (0.68) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL13929497 | 0.78 | APP (0.70) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL5101416 | 0.78 | PDE5A (0.72) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL2583554 | 0.76 | MEN1 (1.00) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL4867531 | 0.75 | MEN1 (0.76) | MEN1KMT2ALMNAMAPTPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140316130-A1 | USE OF MICROFABRICATED DEVICES | HAMMERSMITH IMANET LIMITED (GB) | 2014-10-23 | — | — | US | disclosed |
| EP-2528606-B1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | LEVITZKI ALEXANDER (IL) | 2014-09-24 | — | — | EP | disclosed |
| US-8759363-B2 | Quinazoline-based T cell proliferation inhibitors | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2014-06-24 | — | — | US | disclosed |
| US-20130109706-A1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERSALEM LTD. (IL) | 2013-05-02 | — | — | US | disclosed |
| EP-2528606-A1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011092695-A1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2011-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109706-A1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | IL2, CD4, NFATC1 | MEN1 3730/4885KMT2A 1486/4885LMNA 4669/4885 |
| US-20140316130-A1 | USE OF MICROFABRICATED DEVICES | MPI, MEN1, TMEM14C | MEN1 2/4885KMT2A 1661/4885LMNA 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.