Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | ATM | Q13315 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22947659 | 1.00 | MAPT (0.40) | MAPTALDH1A1HPGDSMN1; SMN2ATM | |
| SCHEMBL22947558 | 0.97 | ALDH1A1 (0.40) | MAPTALDH1A1HPGDSMN1; SMN2ATM | |
| SCHEMBL22949670 | 0.96 | MAPT (0.41) | MAPTALDH1A1HPGDSMN1; SMN2ATM | |
| SCHEMBL22949691 | 0.95 | MAPT (0.39) | MAPTALDH1A1HPGDSMN1; SMN2ATM | |
| SCHEMBL22947667 | 0.95 | MAPT (0.39) | MAPTALDH1A1HPGDSMN1; SMN2ATM | |
| SCHEMBL22947656 | 0.94 | MAPT (0.38) | MAPTALDH1A1HPGDSMN1; SMN2ATM | |
| SCHEMBL22949381 | 0.92 | MAPT (0.39) | MAPTALDH1A1HPGDSMN1; SMN2ATM | |
| SCHEMBL22949123 | 0.92 | ALDH1A1 (0.39) | MAPTALDH1A1HPGDSMN1; SMN2ATM | |
| SCHEMBL22947598 | 0.91 | MAPT (0.40) | MAPTALDH1A1HPGDSMN1; SMN2ATM | |
| SCHEMBL22947665 | 0.89 | MAPT (0.36) | MAPTALDH1A1HPGDSMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210036245-A1 | HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2021-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210036245-A1 | HETEROAROMATIC COMPOUNDS | ETV6, FES, LEF1 | MAPT 3103/4885ALDH1A1 752/4885HPGD 2601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.