Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17887924 | 0.79 | ALOX15 (0.61) | ALOX15OPRM1ALDH1A1KDM4ELMNA | |
| SCHEMBL15329166 | 0.79 | ALOX15 (1.00) | ALOX15ALDH1A1KDM4ELMNAKAT2B | |
| SCHEMBL4523921 | 0.78 | ALOX15 (0.59) | ALOX15OPRM1ALDH1A1KDM4ELMNA | |
| SCHEMBL21637922 | 0.77 | ALOX15 (0.61) | ALOX15OPRM1ALDH1A1KDM4ELMNA | |
| SCHEMBL1953418 | 0.76 | ALOX15 (0.85) | ALOX15ALDH1A1KDM4ELMNAKAT2B | |
| SCHEMBL4515060 | 0.76 | ALOX15 (0.85) | ALOX15OPRM1ALDH1A1KDM4ELMNA | |
| SCHEMBL4498933 | 0.75 | ALOX15 (0.64) | ALOX15OPRM1ALDH1A1KDM4ELMNA | |
| SCHEMBL18325377 | 0.74 | ALOX15 (0.81) | ALOX15ALDH1A1KDM4ELMNAKAT2B | |
| SCHEMBL807358 | 0.74 | ALOX15 (0.81) | ALOX15ALDH1A1KDM4ELMNAKAT2B | |
| SCHEMBL14197731 | 0.73 | ALOX15 (0.62) | ALOX15OPRM1ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |
| WO-2004111045-A1 | PYRROLIDINE - 2- ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |