Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295430 | 0.78 | ALOX15 (0.65) | ALOX15OPRM1KAT2BCD274PDCD1 | |
| SCHEMBL17887924 | 0.75 | ALOX15 (0.61) | ALOX15OPRM1KAT2BHTR4KDM4E | |
| SCHEMBL15329166 | 0.75 | ALOX15 (1.00) | ALOX15KAT2BHTR4KDM4ETAAR1 | |
| SCHEMBL17887877 | 0.75 | TAAR1 (0.45) | ALOX15OPRM1KAT2BKDM4EMAPT | |
| SCHEMBL14197731 | 0.73 | ALOX15 (0.62) | ALOX15OPRM1KAT2BHTR4KDM4E | |
| SCHEMBL14375217 | 0.72 | ALOX15 (0.71) | ALOX15OPRM1KAT2BHTR4KDM4E | |
| SCHEMBL4515060 | 0.72 | ALOX15 (0.85) | ALOX15OPRM1KAT2BKDM4EMAPT | |
| SCHEMBL1953418 | 0.72 | ALOX15 (0.85) | ALOX15KAT2BKDM4EMAPTTDP1 | |
| SCHEMBL5151262 | 0.71 | ALOX15 (0.82) | ALOX15KAT2BHTR4KDM4EMAPT | |
| SCHEMBL4498933 | 0.71 | ALOX15 (0.64) | ALOX15OPRM1KAT2BHTR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482374-B2 | Pyrrolidine-2-ones as Factor Xa inhibitors | GLAXO GROUP LIMITED (GB) | 2009-01-27 | — | — | US | disclosed |
| US-7482374-B2 | Pyrrolidine-2-ones as Factor Xa inhibitors | GLAXO GROUP LIMITED (GB) | 2009-01-27 | — | — | US | disclosed |
| US-7482374-B2 | Pyrrolidine-2-ones as Factor Xa inhibitors | GLAXO GROUP LIMITED (GB) | 2009-01-27 | — | — | US | disclosed |
| US-20060167079-A1 | Pyrrolidine -2-ones as factor xa inhibitors | GLAXO GROUP LIMITED (GB) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167079-A1 | Pyrrolidine -2-ones as factor xa inhibitors | TFPI, F2, F11 | ALOX15 1843/4885OPRM1 1461/4885KAT2B 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.