Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 3/20 | 0.41 |
| ▸ | FPR1 | P21462 | 2/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14152796 | 1.00 | KMT2A (0.48) | KMT2ANPC1RAB9AEPHX2THRB | |
| SCHEMBL2299286 | 1.00 | KMT2A (0.48) | KMT2ANPC1RAB9AEPHX2THRB | |
| SCHEMBL2298347 | 0.92 | KMT2A (0.51) | KMT2ANPC1RAB9AEPHX2THRB | |
| SCHEMBL14151538 | 0.89 | KMT2A (0.50) | KMT2ANPC1RAB9AEPHX2THRB | |
| SCHEMBL2303512 | 0.83 | HTT (0.47) | KMT2AEPHX2MEN1KDM4ELMNA | |
| SCHEMBL14151936 | 0.83 | HTT (0.47) | KMT2AEPHX2MEN1KDM4ELMNA | |
| SCHEMBL14151661 | 0.83 | ALDH1A1 (0.42) | KMT2ANPC1RAB9AEPHX2THRB | |
| SCHEMBL14152150 | 0.83 | EPHX2 (0.45) | KMT2ARAB9AEPHX2GPR183MEN1 | |
| SCHEMBL10380723 | 0.83 | THRB (0.48) | KMT2ANPC1RAB9AEPHX2THRB | |
| SCHEMBL14151454 | 0.82 | RXFP1 (0.48) | KMT2AEPHX2THRBGPR183ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2538787-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011103546-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-08-25 | — | — | WO | disclosed |