Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.41 |
| ▸ | LGMN | Q99538 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22954651 | 0.87 | FFAR4 (0.41) | MAPTFFAR4PDE3BPDE3APDK2 | |
| SCHEMBL22955203 | 0.84 | ALDH1A1 (0.58) | MAPTFFAR4ALDH1A1LMNAMEN1 | |
| SCHEMBL3311124 | 0.84 | MAPT (0.57) | MAPTLGMNPDE3BPDE3APDK2 | |
| SCHEMBL18812811 | 0.78 | CYP3A4 (0.61) | MAPTHSD17B10CYP3A4USP2ALDH1A1 | |
| SCHEMBL20472809 | 0.77 | CYP3A4 (0.49) | FFAR4HSD17B10CYP3A4USP2ALDH1A1 | |
| SCHEMBL17411139 | 0.76 | FFAR4 (0.40) | MAPTFFAR4HSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL7209201 | 0.75 | LGMN (0.51) | MAPTLGMNPDK2NEK2HSD17B10 | |
| SCHEMBL12856205 | 0.75 | LGMN (0.51) | MAPTLGMNNEK2HSD17B10CYP3A4 | |
| SCHEMBL12312271 | 0.75 | GAK (0.53) | MAPTLGMNPDK2NEK2HSD17B10 | |
| SCHEMBL27196623 | 0.75 | LGMN (0.61) | MAPTLGMNPDE3BPDE3APDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018118-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 PROTEINS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-04 | — | — | WO | disclosed |