SCHEMBL22955474

SCHEMBL22955474

Clc1ccc2[nH]c(-c3cccc4ccccc34)cc2c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.59
MEN1 O00255 4/20 0.59
RAB9A P51151 4/20 0.59
KMT2A Q03164 4/20 0.59
NPC1 O15118 3/20 0.59
ALDH1A1 P00352 3/20 0.59
MAPT P10636 3/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
LMNA P02545 1/20 0.59
CYP19A1 P11511 1/20 0.59
HPGD P15428 2/20 0.49
CYP1A2 P05177 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
CASP3 P42574 1/20 0.49
SENP8 Q96LD8 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
SENP6 Q9GZR1 1/20 0.49
GSK3B P49841 1/20 0.46
CDK5 Q00535 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29808539 1.00 KDM4E (0.59) KDM4EMEN1RAB9AKMT2ANPC1
SCHEMBL29375783 0.83 KDR (0.58) KDM4EMEN1RAB9AKMT2ANPC1
SCHEMBL31591007 0.83 KDR (0.58) KDM4EMEN1RAB9AKMT2ANPC1
SCHEMBL2187575 0.83 KDR (0.58) KDM4EMEN1RAB9AKMT2ANPC1
SCHEMBL27291636 0.81 CDK1 (0.53) KDM4EMEN1KMT2AALDH1A1MAPT
SCHEMBL17065800 0.81 MEN1 (0.63) KDM4EMEN1RAB9AKMT2ANPC1
SCHEMBL10176240 0.79 KDR (0.61) KDM4EMEN1RAB9AKMT2ANPC1
SCHEMBL11488198 0.79 MEN1 (0.61) KDM4EMEN1RAB9AKMT2ANPC1
SCHEMBL28763445 0.79 MEN1 (0.61) KDM4EMEN1RAB9AKMT2ANPC1
SCHEMBL28167722 0.79 MEN1 (0.61) KDM4EMEN1RAB9AKMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125348-A1 ARYL HYDROCARBON RECEPTOR ACTIVATORS OREGON STATE UNIVERSITY (US) 2026-05-07 US disclosed
EP-4710922-A2 ARYL HYDROCARBON RECEPTOR ACTIVATORS Oregon State University (US) 2026-03-18 EP disclosed
EP-4003337-B1 ARYL HYDROCARBON RECEPTOR ACTIVATORS UNIV OREGON STATE (US) 2026-03-11 EP disclosed
US-12473262-B2 Aryl hydrocarbon receptor activators OREGON STATE UNIVERSITY (US) 2025-11-18 US disclosed
US-20220281824-A1 ARYL HYDROCARBON RECEPTOR ACTIVATORS OREGON STATE UNIVERSITY (US) 2022-09-08 US disclosed
WO-2021022061-A1 ARYL HYDROCARBON RECEPTOR ACTIVATORS OREGON STATE UNIVERSITY (US) 2021-02-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220281824-A1 ARYL HYDROCARBON RECEPTOR ACTIVATORS AHR, ARNT, NR0B1 KDM4E 2779/4885MEN1 4811/4885RAB9A 3686/4885
US-20260125348-A1 ARYL HYDROCARBON RECEPTOR ACTIVATORS AHR, ARNT, NR1H2 KDM4E 2619/4885MEN1 4553/4885RAB9A 2472/4885
US-12473262-B2 Aryl hydrocarbon receptor activators AHR, ARNT, NR0B1 KDM4E 2779/4885MEN1 4811/4885RAB9A 3686/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.