Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295690 | 1.00 | MAPT (0.37) | MAPTKCNH2NR3C1ABCB1MEN1 | |
| SCHEMBL12380684 | 1.00 | MAPT (0.37) | MAPTKCNH2NR3C1ABCB1MEN1 | |
| SCHEMBL3576131 | 0.92 | MRGPRX4 (0.40) | MAPTKCNH2NR3C1ABCB1ADRB3 | |
| SCHEMBL3576133 | 0.92 | MRGPRX4 (0.40) | MAPTKCNH2NR3C1ABCB1ADRB3 | |
| SCHEMBL4803191 | 0.91 | KCNH2 (0.38) | KCNH2NR3C1ABCB1ADRB3CSF1R | |
| SCHEMBL4803205 | 0.91 | KCNH2 (0.38) | KCNH2NR3C1ABCB1ADRB3CSF1R | |
| SCHEMBL3287963 | 0.91 | KCNH2 (0.38) | MAPTKCNH2NR3C1ABCB1ADRB3 | |
| SCHEMBL3287965 | 0.91 | KCNH2 (0.38) | MAPTKCNH2NR3C1ABCB1ADRB3 | |
| SCHEMBL3290825 | 0.91 | KCNH2 (0.42) | KCNH2NR3C1ABCB1ADRB3CSF1R | |
| SCHEMBL3290827 | 0.91 | KCNH2 (0.42) | KCNH2NR3C1ABCB1ADRB3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190529-A1 | METHOD FOR PREPARING THE ETHYL ESTER OF 4-[TRANS-4-[(PHENYLMETHYL)-AMINO]CYCLOHEXYL]BENZOIC ACID AND THE HEMIFUMARATE SALT THEREOF | SANOFI-AVENTIS (FR) | 2011-08-04 | — | — | US | disclosed |
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | SANOFI-AVENTIS (FR) | 2010-03-25 | — | — | US | disclosed |
| US-7625929-B2 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics | SANOFI-AVENTIS (FR) | 2009-12-01 | — | — | US | disclosed |
| US-7453010-B2 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI AVENTIS (FR) | 2008-11-18 | — | — | US | disclosed |
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI-AVENTIS (FR) | 2006-05-11 | — | — | US | disclosed |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | SANOFI-AVENTIS (FR) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | CHRM1, CHRM2, C1R | MAPT 3646/4885KCNH2 905/4885NR3C1 71/4885 |
| US-20110190529-A1 | METHOD FOR PREPARING THE ETHYL ESTER OF 4-[TRANS-4-[(PHENYLMETHYL)-AMINO]CYCLOHEXYL]BENZOIC ACID AND THE HEMIFUMARATE SALT THEREOF | CYP4F11, CYP51A1, CYP4F2 | MAPT 2085/4885KCNH2 3145/4885NR3C1 3708/4885 |
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | HRH4, HRH3, AOC3 | MAPT 3137/4885KCNH2 136/4885NR3C1 314/4885 |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | HRH4, HRH3, HTR3C | MAPT 2619/4885KCNH2 353/4885NR3C1 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.