Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 11/20 | 0.73 |
| ▸ | THRB | P10828 | 4/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22959145 | 0.90 | RORC (0.58) | RORCTHRBCHEK1CDK9HRH3 | |
| SCHEMBL22959366 | 0.87 | RORC (0.79) | RORCTHRBCHEK1CDK9GAA | |
| SCHEMBL22959380 | 0.85 | RORC (0.75) | RORCTHRBHRH3CRACR2A | |
| SCHEMBL22959272 | 0.84 | RORC (0.75) | RORCTHRBCHEK1CDK9GAA | |
| SCHEMBL22959110 | 0.84 | RORC (1.00) | RORCTHRBCHEK1CDK9 | |
| SCHEMBL22959179 | 0.78 | RORC (0.85) | RORCTHRB | |
| SCHEMBL22959350 | 0.77 | RORC (0.82) | RORCTHRB | |
| SCHEMBL22959177 | 0.76 | RORC (0.80) | RORCTHRBGAAALDH1A1L3MBTL1 | |
| SCHEMBL22959119 | 0.76 | RORC (0.63) | RORCTHRBCDK9GAAALDH1A1 | |
| SCHEMBL22959408 | 0.76 | RORC (1.00) | RORCTHRBCHEK1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026179-A1 | AGONISTS OF ROR GAMMAt | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-02-11 | — | — | WO | disclosed |