Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 12/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SNCA | P37840 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22960576 | 0.87 | NOX1 (0.70) | NOX1KCNH2BCHEACHEGAA | |
| SCHEMBL22960441 | 0.86 | NOX1 (0.65) | NOX1KCNH2BCHEACHEGAA | |
| SCHEMBL22960643 | 0.85 | NOX1 (0.63) | NOX1KCNH2BCHEACHEGAA | |
| SCHEMBL22960644 | 0.84 | NOX1 (0.66) | NOX1KCNH2BCHEACHEGAA | |
| SCHEMBL22960439 | 0.84 | NOX1 (0.62) | NOX1KCNH2BCHEACHEGAA | |
| SCHEMBL22960596 | 0.84 | NOX1 (0.66) | NOX1KCNH2BCHEACHEGAA | |
| SCHEMBL29449428 | 0.84 | NOX1 (0.66) | NOX1KCNH2BCHEACHEGAA | |
| SCHEMBL22960461 | 0.84 | NOX1 (0.62) | NOX1KCNH2BCHEACHEGAA | |
| SCHEMBL22960682 | 0.84 | NOX1 (0.62) | NOX1KCNH2BCHEACHEGAA | |
| SCHEMBL29449456 | 0.84 | NOX1 (0.66) | NOX1KCNH2BCHEACHEGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114181170-B | 10H-phenothiazine iron death inhibitor and preparation method and application thereof | 成都恒昊创新科技有限公司 | 2023-03-10 | — | — | CN | disclosed |
| CN-114181170-A | 10H-phenothiazine iron death inhibitor and preparation method and application thereof | 成都恒昊创新科技有限公司 | 2022-03-15 | — | — | CN | disclosed |
| CN-108484527-B | 10H-phenothiazine iron death inhibitor and preparation method and application thereof | 成都恒昊创新科技有限公司 | 2022-01-14 | — | — | CN | disclosed |
| EP-3786156-A1 | 10H-PHENOTHIAZINE FERROPTOSIS INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Chengdu Henghao Investment Co. Limited (CN) | 2021-03-03 | — | — | EP | disclosed |
| EP-3786156-A1 | 10H-PHENOTHIAZINE FERROPTOSIS INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Chengdu Henghao Investment Co. Limited (CN) | 2021-03-03 | — | — | EP | disclosed |
| US-20210040079-A1 | 10H-phenothiazine ferroptosis inhibitor as well as the preparative method and the use thereof | Chengdu Henghao Investment Co. Limited (CN) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040079-A1 | 10H-phenothiazine ferroptosis inhibitor as well as the preparative method and the use thereof | AIFM2, FECH, GPX4 | NOX1 1192/4885KCNH2 2324/4885BCHE 3693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.