Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estrone Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.96 |
| ▸ | STS | P08842 | 11/20 | 0.80 |
| ▸ | CA1 | P00915 | 3/20 | 0.80 |
| ▸ | CA2 | P00918 | 3/20 | 0.80 |
| ▸ | CA9 | Q16790 | 3/20 | 0.80 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.80 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.80 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.80 |
| ▸ | CA4 | P22748 | 1/20 | 0.80 |
| ▸ | CA6 | P23280 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estrone Sulfuric Acid SCHEMBL4616 | 1.00 | KDM4E (0.96) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL29950318 | 1.00 | KDM4E (0.96) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL4812138 | 1.00 | KDM4E (0.96) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL8901903 | 0.98 | KDM4E (1.00) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL939946 | 0.98 | KDM4E (1.00) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL28077672 | 0.98 | KDM4E (1.00) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL21067318 | 0.91 | STS (0.84) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL29379988 | 0.90 | STS (0.98) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL8034430 | 0.90 | STS (0.82) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL17531381 | 0.90 | STS (0.82) | KDM4ESTSCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539435-A2 | MODIFIED SUBSTRATES FOR PROTECTION OF PEPTIDE-IMMOBILIZED SURFACES FROM GAMMA RADIATION DEGRADATION | Corning Incorporated (US) | 2013-01-02 | — | — | EP | claimed |
| WO-2011106222-A2 | MODIFIED SUBSTRATES FOR PROTECTION OF PEPTIDE-IMMOBILIZED SURFACES FROM GAMMA RADIATION DEGRADATION | CORNING INCORPORATED (US) | 2011-09-01 | — | — | WO | claimed |
| US-20110207219-A1 | MODIFIED SUBSTRATES FOR PROTECTION OF PEPTIDE-IMMOBILIZED SURFACES FROM GAMMA RADIATION DEGRADATION | CORNING INCORPORATED | 2011-08-25 | — | — | US | claimed |
| WO-1998016232-A1 | USE OF 8,9-DEHYDROESTRONE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF VASOMOTOR SYMPTOMS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-23 | — | — | WO | claimed |
| EP-0424954-B1 | Pharmaceutical composition for treatment of osteoporosis | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 1994-04-27 | — | — | EP | claimed |
| US-5116828-A | Estrogen and thyroid hormone | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1992-05-26 | — | — | US | claimed |
| EP-0424954-A1 | Pharmaceutical composition for treatment of osteoporosis | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1991-05-02 | — | — | EP | claimed |
| US-20230285565-A1 | POLYTETRAFLUOROETHYLENE CO-POLYMER EMULSIONS | W. L. GORE & ASSOCIATES, INC. | 2023-09-14 | — | — | US | disclosed |
| US-11642412-B2 | Polytetrafluoroethylene co-polymer emulsions | W. L. GORE & ASSOCIATES, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-20220401626-A1 | LIQUID COMPOSITION AND POROUS HARDENED MATERIAL COMPRISING TETRAFLUOROETHYLENE AND VINYL MOIETY CO-POLYMERS | W. L. GORE & ASSOCIATES, INC. | 2022-12-22 | — | — | US | disclosed |
| WO-2021097210-A1 | LIQUID COMPOSITION AND POROUS HARDENED MATERIAL COMPRISING TETRAFLUOROETHYLENE AND VINYL MOIETY CO-POLYMERS | W. L. GORE & ASSOCIATES, INC. (US) | 2021-05-20 | — | — | WO | disclosed |
| US-10688188-B2 | Polytetrafluoroethylene co-polymer emulsions | W. L. GORE & ASSOCIATES, INC. (US) | 2020-06-23 | — | — | US | disclosed |
| EP-2895210-B1 | POLYTETRAFLUOROETHYLENE CO-POLYMER EMULSIONS | GORE & ASS (US) | 2020-02-12 | — | — | EP | disclosed |
| US-20140072518-A1 | POLYTETRAFLUOROETHYLENE CO-POLYMER EMULSIONS | W. L. GORE & ASSOCIATES, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-20140072514-A1 | POLYTETRAFLUOROETHYLENE CO-POLYMER EMULSIONS | W. L. GORE & ASSOCIATES, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| EP-0829263-A1 | Use of 8,9-dehydroestrone in estrogen therapy | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-18 | — | — | EP | disclosed |
| EP-0424954-B1 | Pharmaceutical composition for treatment of osteoporosis | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 1994-04-27 | — | — | EP | disclosed |
| US-5116828-A | Estrogen and thyroid hormone | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0424954-A1 | Pharmaceutical composition for treatment of osteoporosis | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1991-05-02 | — | — | EP | disclosed |
| US-4113751-A | SODIUM ACETATE | SCHERING AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |