Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estrone Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.96 |
| ▸ | STS | P08842 | 11/20 | 0.80 |
| ▸ | CA1 | P00915 | 3/20 | 0.80 |
| ▸ | CA2 | P00918 | 3/20 | 0.80 |
| ▸ | CA9 | Q16790 | 3/20 | 0.80 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.80 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.80 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.80 |
| ▸ | CA4 | P22748 | 1/20 | 0.80 |
| ▸ | CA6 | P23280 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estrone Sulfuric Acid SCHEMBL4616 | 1.00 | KDM4E (0.96) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL2296097 | 1.00 | KDM4E (0.96) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL4812138 | 1.00 | KDM4E (0.96) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL8901903 | 0.98 | KDM4E (1.00) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL939946 | 0.98 | KDM4E (1.00) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL28077672 | 0.98 | KDM4E (1.00) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL21067318 | 0.91 | STS (0.84) | KDM4ESTSCA1CA2CA9 | |
| Estrone Sulfuric Acid SCHEMBL29379988 | 0.90 | STS (0.98) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL8034430 | 0.90 | STS (0.82) | KDM4ESTSCA1CA2CA9 | |
| SCHEMBL17531381 | 0.90 | STS (0.82) | KDM4ESTSCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119365466-A | Tricyclic pyridones and pyrimidinones | 医睿世康药业研发公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-221510680-U | Box is raised to armyworm | 中国农业科学院草原研究所 | 2024-08-13 | — | — | CN | disclosed |
| US-12029932-B2 | Mixture of non-polymer organic components with fire retardancy, preparation method and use | PRIMALCHIT SOLUTIONS, S.L. (ES) | 2024-07-09 | — | — | US | disclosed |
| CN-117866225-A | Metal organic gel for detecting estrone and application thereof | 哈深迪(广东)生物科技有限公司 | 2024-04-12 | — | — | CN | disclosed |
| US-20230414512-A1 | Dermal Delivery Compositions Comprising Active Agent-Calcium Phosphate Particle Complexes and Methods of Using the Same | LABORATORY SKIN CARE, INC. | 2023-12-28 | — | — | US | disclosed |
| US-20230285565-A1 | POLYTETRAFLUOROETHYLENE CO-POLYMER EMULSIONS | W. L. GORE & ASSOCIATES, INC. | 2023-09-14 | — | — | US | disclosed |
| CN-116656771-A | Detection method for judging whether test object is SLC transporter substrate or inhibitor | 江苏鼎泰药物研究(集团)股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4218718-A2 | DERMAL DELIVERY COMPOSITIONS COMPRISING ACTIVE AGENT-CALCIUM PHOSPHATE PARTICLE COMPLEXES AND METHODS OF USING THE SAME | Laboratory Skin Care, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| US-11642412-B2 | Polytetrafluoroethylene co-polymer emulsions | W. L. GORE & ASSOCIATES, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-20230045206-A1 | Mixture of Non-Polymer Organic Components with Fire Retardancy, Preparation Method and Use | PRIMALCHIT SOLUTIONS, S.L. (ES) | 2023-02-09 | — | — | US | disclosed |
| EP-2427178-B1 | DERMAL DELIVERY COMPOSITIONS COMPRISING ACTIVE AGENT-CALCIUM PHOSPHATE PARTICLE COMPLEXES AND METHODS OF USING THE SAME | LABORATORY SKIN CARE INC (US) | 2023-01-04 | — | — | EP | disclosed |
| US-20220401626-A1 | LIQUID COMPOSITION AND POROUS HARDENED MATERIAL COMPRISING TETRAFLUOROETHYLENE AND VINYL MOIETY CO-POLYMERS | W. L. GORE & ASSOCIATES, INC. | 2022-12-22 | — | — | US | disclosed |
| US-20220362330-A1 | Compositions and Methods for Increasing Epithelial Barrier Function | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-11-17 | — | — | US | disclosed |
| EP-4085976-A1 | MIXTURE OF NON-POLYMER ORGANIC COMPONENTS WITH FIRE RETARDANCY, PREPARATION METHOD AND USE | Primalchit Solutions, S.L. (ES) | 2022-11-09 | — | — | EP | disclosed |
| EP-4058073-A1 | LIQUID COMPOSITION AND POROUS HARDENED MATERIAL COMPRISING TETRAFLUOROETHYLENE AND VINYL MOIETY CO-POLYMERS | W.L. Gore & Associates, Inc. (US) | 2022-09-21 | — | — | EP | disclosed |