Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19440160 | 0.81 | CSNK2A1 (0.47) | ALDH1A1LMNANPSR1CYP2C19MEN1 | |
| SCHEMBL10359297 | 0.81 | ALDH1A1 (0.68) | ALDH1A1LMNANPSR1CYP2C19MEN1 | |
| SCHEMBL22596995 | 0.80 | L3MBTL1 (0.50) | ALDH1A1LMNANPSR1CYP2C19MEN1 | |
| SCHEMBL21477276 | 0.79 | ALDH1A1 (0.49) | ALDH1A1LMNANPSR1CYP2C19MEN1 | |
| SCHEMBL22714464 | 0.79 | L3MBTL1 (0.45) | ALDH1A1LMNANPSR1CYP2C19MEN1 | |
| SCHEMBL10358917 | 0.78 | MAPT (0.65) | ALDH1A1LMNANPSR1CYP2C19MEN1 | |
| SCHEMBL13184060 | 0.78 | ALDH1A1 (0.47) | ALDH1A1LMNANPSR1CYP2C19MEN1 | |
| SCHEMBL11069560 | 0.78 | ALDH1A1 (0.44) | ALDH1A1LMNANPSR1CYP2C19MEN1 | |
| SCHEMBL21465857 | 0.77 | ALDH1A1 (0.45) | ALDH1A1LMNANPSR1CYP2C19MEN1 | |
| SCHEMBL13672486 | 0.74 | KDM4E (0.40) | ALDH1A1MAPTKMT2AL3MBTL1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961231-B2 | NTCP inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-03-30 | — | — | US | disclosed |
| US-20210040072-A1 | NTCP Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040072-A1 | NTCP Inhibitors | HAVCR2, NPC1, HMGCR | ALDH1A1 4749/4885LMNA 3338/4885NPSR1 1396/4885 |
| US-10961231-B2 | NTCP inhibitors | HAVCR2, NPC1, HMGCR | ALDH1A1 4749/4885LMNA 3338/4885NPSR1 1396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.