Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | LGMN | Q99538 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.45 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.45 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4507051 | 0.83 | AGXT (0.65) | AGXTLMNAKMOSIGMAR1TMEM97 | |
| SCHEMBL671148 | 0.83 | AGXT (0.65) | AGXTLMNAKMOSIGMAR1TMEM97 | |
| SCHEMBL18295011 | 0.83 | AGXT (0.65) | AGXTLMNAKMOSIGMAR1TMEM97 | |
| SCHEMBL29867053 | 0.83 | AGXT (0.65) | AGXTLMNAKMOSIGMAR1TMEM97 | |
| SCHEMBL9302706 | 0.83 | AGXT (0.65) | AGXTLMNAKMOSIGMAR1TMEM97 | |
| SCHEMBL108136 | 0.83 | AGXT (0.69) | AGXTLMNAKMOSIGMAR1TMEM97 | |
| SCHEMBL23662605 | 0.81 | AGXT (0.63) | AGXTLMNAKMOSIGMAR1TMEM97 | |
| SCHEMBL27329825 | 0.81 | LMNA (0.71) | AGXTLMNAKMOLGMNDHFR | |
| SCHEMBL13725027 | 0.80 | AGXT (0.66) | AGXTLMNAKMOSIGMAR1TMEM97 | |
| SCHEMBL425652 | 0.80 | AGXT (0.66) | AGXTLMNAKMOSIGMAR1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961231-B2 | NTCP inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-03-30 | — | — | US | disclosed |
| US-20210040072-A1 | NTCP Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040072-A1 | NTCP Inhibitors | HAVCR2, NPC1, HMGCR | AGXT 667/4885LMNA 3338/4885KMO 2904/4885 |
| US-10961231-B2 | NTCP inhibitors | HAVCR2, NPC1, HMGCR | AGXT 667/4885LMNA 3338/4885KMO 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.