SCHEMBL22965205

SCHEMBL22965205

COc1ccc(C2=Cc3ccc4c(c3OC2)CCC(C)(C)O4)c(OS(=O)(=O)c2ccc(C)cc2)c1

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MALT1 Q9UDY8 2/20 0.37
▸ MAPT P10636 1/20 0.34
▸ PLCG2 P16885 1/20 0.34
▸ PDE4D Q08499 1/20 0.33
▸ NFKB1 P19838 1/20 0.32
▸ NFKB2 Q00653 1/20 0.32
▸ RELA Q04206 1/20 0.32
▸ CNR2 P34972 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ GRM2 Q14416 1/20 0.32
▸ HSP90AA1 P07900 1/20 0.32
▸ PTPN1 P18031 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21454332 0.88 CNR2 (0.36) CNR2HSP90AA1PTPN1
SCHEMBL21254126 0.82 ACHE (0.41) MAPTPDE4DSMN1; SMN2HSP90AA1PTPN1
SCHEMBL21454562 0.81 PTPN1 (0.41) PTPN1
SCHEMBL21447064 0.80 PTPN1 (0.44) MALT1GRM2HSP90AA1PTPN1
SCHEMBL21454602 0.79 MALT1 (0.37) MALT1MAPTPLCG2CNR2GRM2
SCHEMBL21436843 0.76 PTPN1 (0.32) PTPN1
SCHEMBL22965202 0.75 PTPN1 (0.37) MALT1MAPTPLCG2CNR2HSP90AA1
SCHEMBL21254262 0.74 TYR (0.38) MAPTCNR2KMT2ASMN1; SMN2HSP90AA1
SCHEMBL21447037 0.73 HSP90AA1 (0.40) PDE4DHSP90AA1PTPN1
SCHEMBL21447076 0.72 PTPN1 (0.41) PDE4DGRM2HSP90AA1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3782999-B1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE GLACEUM INC (KR) 2023-05-10 — — EP disclosed
EP-3782999-A1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE Glaceum, Inc. (KR) 2021-02-24 — — EP disclosed
US-20210040106-A1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE Glaceum Inc. (KR) 2021-02-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210040106-A1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE HPD, CYP2J2, PAH MALT1 3699/4885MAPT 3047/4885PLCG2 2687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback