Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 11/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 7/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.56 |
| ▸ | FOS | P01100 | 2/20 | 0.56 |
| ▸ | TTR | P02766 | 2/20 | 0.56 |
| ▸ | JUN | P05412 | 2/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.56 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16001568 | 0.84 | ALOX15 (0.67) | ALOX15ALOX12CYP3A4KDM4EMEN1 | |
| SCHEMBL16001530 | 0.84 | ALOX15 (0.67) | ALOX15ALOX12CYP3A4KDM4EMEN1 | |
| SCHEMBL16001528 | 0.84 | ALOX15 (0.67) | ALOX15ALOX12CYP3A4KDM4EMEN1 | |
| SCHEMBL17693595 | 0.81 | ALOX15 (0.43) | ALOX15ALOX12CYP3A4KDM4EMEN1 | |
| SCHEMBL16001527 | 0.79 | ALOX15 (0.63) | ALOX15ALOX12CYP3A4KDM4EMEN1 | |
| SCHEMBL16001796 | 0.79 | ALOX15 (0.63) | ALOX15ALOX12CYP3A4KDM4EMEN1 | |
| SCHEMBL16001526 | 0.79 | ALOX15 (0.63) | ALOX15ALOX12CYP3A4KDM4EMEN1 | |
| SCHEMBL20921973 | 0.79 | SLC7A5 (0.56) | ALOX15KDM4EMEN1RECQLKMT2A | |
| SCHEMBL17693637 | 0.79 | SLC7A5 (0.56) | ALOX15KDM4EMEN1RECQLKMT2A | |
| SCHEMBL17685909 | 0.78 | ALDH1A1 (0.46) | ALOX15ALOX12CYP3A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026257-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | EMPIRICO INC. (US) | 2021-02-11 | — | — | WO | disclosed |