Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AQP1 | P29972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10296345 | 0.81 | JAK2 (0.33) | — | |
| SCHEMBL27281802 | 0.81 | JAK2 (0.33) | — | |
| SCHEMBL12162527 | 0.76 | AQP1 (0.32) | KDM4EGAAAQP1 | |
| SCHEMBL22855610 | 0.75 | TSHR (0.34) | TSHRSMN1; SMN2 | |
| SCHEMBL24789946 | 0.75 | KDM4E (0.36) | KDM4EGAAHSD11B1 | |
| SCHEMBL24734651 | 0.75 | KDM4E (0.36) | KDM4EGAAHSD11B1 | |
| SCHEMBL3390865 | 0.75 | — | — | |
| SCHEMBL734650 | 0.73 | KEAP1 (0.37) | SMN1; SMN2 | |
| SCHEMBL1569268 | 0.71 | KDM4E (0.47) | KDM4E | |
| SCHEMBL1569264 | 0.71 | KDM4E (0.47) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026099-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2021-02-11 | — | — | WO | disclosed |