Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22969883 | 1.00 | CA1 (0.30) | CA1CA2CA9 | |
| SCHEMBL21040789 | 1.00 | CA1 (0.30) | CA1CA2CA9 | |
| SCHEMBL17542344 | 1.00 | CA1 (0.30) | CA1CA2CA9 | |
| SCHEMBL18662887 | 1.00 | CA1 (0.30) | CA1CA2CA9 | |
| SCHEMBL17542433 | 1.00 | CA1 (0.30) | CA1CA2CA9 | |
| SCHEMBL17550210 | 1.00 | CA1 (0.30) | CA1CA2CA9 | |
| SCHEMBL20637970 | 0.85 | MMP9 (0.33) | CA1CA2 | |
| SCHEMBL17542346 | 0.85 | MMP9 (0.33) | CA1CA2 | |
| SCHEMBL17542216 | 0.85 | MMP9 (0.33) | CA1CA2 | |
| SCHEMBL20629643 | 0.85 | MMP9 (0.33) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210040120-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040120-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | MCL1, BCL2L1, BCL9 | CA1 4617/4885CA2 4729/4885CA9 4730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.