Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4322579 | 0.89 | GPR119 (0.65) | GPR119MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1277296 | 0.88 | CSF1R (0.46) | GPR119MEN1KMT2ANAMPTALDH1A1 | |
| SCHEMBL1277324 | 0.83 | MEN1 (0.44) | GPR119MEN1KMT2ANAMPT | |
| SCHEMBL31071572 | 0.81 | GPR119 (0.53) | GPR119MEN1KMT2AALDH1A1CHEK2 | |
| SCHEMBL20610299 | 0.80 | NAMPT (0.54) | NAMPTALDH1A1 | |
| SCHEMBL28994953 | 0.80 | GPR119 (0.60) | GPR119KMT2ACHEK2 | |
| SCHEMBL28994863 | 0.80 | GPR119 (0.60) | GPR119KMT2ACHEK2 | |
| SCHEMBL5220425 | 0.79 | MEN1 (0.50) | MEN1KMT2ANAMPTALDH1A1LMNA | |
| SCHEMBL17729089 | 0.79 | CHEK2 (0.56) | GPR119MEN1KMT2ALMNACHEK2 | |
| SCHEMBL31270200 | 0.78 | GPR119 (0.45) | GPR119NAMPTCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |