Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669048 | 0.80 | NOS1 (0.39) | CBLBNOS1GAAMAPTRAB9A | |
| SCHEMBL18214837 | 0.75 | NOS1 (0.41) | CBLBNOS1GAALMNAMAPT | |
| SCHEMBL25619472 | 0.75 | NOS1 (0.41) | CBLBNOS1GAALMNAMAPT | |
| SCHEMBL31030377 | 0.75 | HPGD (0.38) | NOS1GAALMNATSHRMAPT | |
| SCHEMBL21266850 | 0.74 | JAK2 (0.34) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL19504430 | 0.73 | GAA (0.41) | CBLBNOS1GAAMAPTRAB9A | |
| SCHEMBL10049910 | 0.73 | GAA (0.37) | CBLBNOS1GAAMAPTRAB9A | |
| SCHEMBL29300697 | 0.72 | GAA (0.36) | CBLBNOS1GAALMNAMAPT | |
| SCHEMBL6972157 | 0.71 | GAA (0.38) | CBLBNOS1GAALMNAMAPT | |
| SCHEMBL23985340 | 0.70 | DRD2 (0.39) | CBLBNOS1GAAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11286248-B2 | Pyrazine-2(1H)-ketone compound acting as FGFR inhibitor | ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. (CN) | 2022-03-29 | — | — | US | disclosed |
| US-20210040070-A1 | PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR | ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. (CN) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040070-A1 | PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR | FGFR1, FGFR2, FGFR3 | CBLB 4272/4885NOS1 4099/4885GAA 1140/4885 |
| US-11286248-B2 | Pyrazine-2(1H)-ketone compound acting as FGFR inhibitor | FGFR1, FGFR2, FGFR3 | CBLB 4272/4885NOS1 4099/4885GAA 1140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.