Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 2/20 | 0.59 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29072109 | 0.91 | KLK7 (0.60) | KLK7KLK5MAPTABCB1FOLH1 | |
| SCHEMBL29072115 | 0.91 | KLK7 (0.60) | KLK7KLK5MAPTABCB1FOLH1 | |
| SCHEMBL28902004 | 0.90 | KLK7 (0.59) | KLK7KLK5MAPTABCB1FOLH1 | |
| SCHEMBL28902002 | 0.90 | KLK7 (0.59) | KLK7KLK5MAPTABCB1FOLH1 | |
| SCHEMBL1303931 | 0.89 | MAPT (0.68) | KLK7KLK5MAPTABCB1FOLH1 | |
| SCHEMBL17309872 | 0.89 | MAPT (0.68) | KLK7KLK5MAPTABCB1FOLH1 | |
| SCHEMBL29460388 | 0.89 | KLK7 (0.61) | KLK7KLK5MAPTABCB1FOLH1 | |
| SCHEMBL29727709 | 0.87 | KLK7 (0.57) | KLK7KLK5MAPTABCB1FOLH1 | |
| SCHEMBL20450594 | 0.87 | FOLH1 (0.60) | KLK7KLK5MAPTABCB1FOLH1 | |
| SCHEMBL20450593 | 0.87 | FOLH1 (0.60) | KLK7KLK5MAPTABCB1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778597-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USES THEREOF | SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN) | 2025-05-28 | — | — | EP | disclosed |
| US-11541049-B2 | Tetrahydroisoquinoline derivatives, preparation process and use thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-01-03 | — | — | US | disclosed |
| US-20210052576-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2021-02-25 | — | — | US | disclosed |
| EP-3778597-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USES THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2021-02-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11541049-B2 | Tetrahydroisoquinoline derivatives, preparation process and use thereof | CYP3A4, CYP3A43, CYP11B2 | KLK7 2428/4885KLK5 1372/4885MAPT 81/4885 |
| US-20210052576-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | CYP3A4, CYP3A43, CYP11B2 | KLK7 2428/4885KLK5 1372/4885MAPT 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.