Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2749099 | 0.90 | MAPT (0.46) | HCAR3ALDH1A1KDM4ECYP3A4MAPK1 | |
| SCHEMBL1265187 | 0.86 | HCAR3 (0.46) | HCAR3ALDH1A1KDM4EMAPK1TDP1 | |
| SCHEMBL12382095 | 0.78 | LCK (0.37) | MAPK1TSHRTDP1MAPTNPSR1 | |
| SCHEMBL1263855 | 0.78 | HCAR3 (0.48) | HCAR3ALDH1A1KDM4EMAPTNPSR1 | |
| SCHEMBL2971735 | 0.78 | ALDH1A1 (0.56) | HCAR3ALDH1A1KDM4EMAPK1TSHR | |
| SCHEMBL7954120 | 0.75 | ALDH1A1 (0.62) | HCAR3ALDH1A1KDM4ECYP3A4MAPK1 | |
| SCHEMBL1263874 | 0.74 | HCAR3 (0.45) | HCAR3ALDH1A1KDM4EMAPTNPSR1 | |
| SCHEMBL1959419 | 0.74 | SMN1; SMN2 (0.62) | HCAR3ALDH1A1KDM4ETDP1MAPT | |
| SCHEMBL1264437 | 0.73 | HCAR3 (0.44) | HCAR3ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL1408112 | 0.73 | ALDH1A1 (0.46) | ALDH1A1MAPK1MAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476434-B2 | Protein kinase modulators and method of use | AMGEN INC. (US) | 2013-07-02 | — | — | US | disclosed |
| US-20110201602-A1 | PROTEIN KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201602-A1 | PROTEIN KINASE MODULATORS AND METHOD OF USE | GRK4, MAP4K5, GRK5 | HCAR3 1162/4885ALDH1A1 3475/4885KDM4E 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.