Known targets — ChEMBL curated mechanism
COXFA4COXFA4L2GPD2MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3
The experimentally established mechanism targets of Metformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metformin SCHEMBL15268394 | 1.00 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL18953625 | 1.00 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL19583451 | 1.00 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL1547913 | 1.00 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL4421557 | 1.00 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL433864 | 1.00 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL28854120 | 0.97 | HTT (0.37) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL1714633 | 0.97 | HTT (0.37) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL1747396 | 0.97 | HTT (0.37) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL4200501 | 0.97 | HTT (0.37) | HTTLMNADPP4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 38930 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075608-A | Preparation method of metformin compound hypoglycemic oral liquid | — | 2026-05-26 | — | — | CN | claimed |
| US-20260137624-A1 | PHARMACEUTICAL COMPOSITION AND USES THEREOF | BOEHRINGER INGELHEIM INT GMBH (DE) | 2026-05-21 | — | — | US | claimed |
| CN-121222332-B | Compression device and compression method for metformin hydrochloride tablets | 北京京丰制药(山东)有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4734978-A2 | COMBINATION THERAPIES USING PSILOCYBIN | University of Padova (IT) | 2026-05-06 | — | — | EP | claimed |
| US-20260115208-A1 | SUSTAINED RELEASE COMPOSITION COMPRISING AN ETHYLCELLULOSE | NUTRITION & BIOSCIENCES USA 1 LLC (US) | 2026-04-30 | — | — | US | claimed |
| EP-4285893-B1 | A COMBINATION COMPRISING EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE | SANOVEL ILAC SANAYI VE TICARET AS (TR) | 2026-04-29 | — | — | EP | claimed |
| US-12599564-B2 | Antidiabetic pharmaceutical compositions | Elite Pharmaceutical Solution Inc. (US) | 2026-04-14 | — | — | US | claimed |
| EP-4709359-A1 | ORAL DOSAGE FORMS OF METFORMIN AND PREPARATION METHOD THEREOF | Elite Pharmaceutical Solution Inc. (US) | 2026-03-18 | — | — | EP | claimed |
| CN-121586575-A | Metformin oral dosage form and method for preparing the same | 赛乐医药科技有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-12553134-B2 | Bendable nickel plating on flexible substrates | MACDERMID ENTHONE INC. (US) | 2026-02-17 | — | — | US | claimed |
| EP-0001039-A1 | Transparent polyamide | BAYER AG (DE) | 1979-03-21 | — | — | EP | claimed |
| EP-0000903-A2 | Carbonless copying paper and manufacture thereof | BAYER AG (DE) | 1979-03-07 | — | — | EP | claimed |
| EP-0000706-A1 | Use of polyimide amine salts as cationic paper surface sizing agents | BAYER AG (DE) | 1979-02-21 | — | — | EP | claimed |
| EP-0000727-A1 | 3-(4-(1,3-Diazacycloalkene-2-yl)-phenyl)-1,2-benzisothiazoles, process for their preparation and medicaments containing them. | BASF Aktiengesellschaft (DE) | 1979-02-21 | — | — | EP | claimed |
| EP-0000507-A1 | Process for the production of hydrogels in the form of spherically shaped beads with larger diameters | CIBA-GEIGY AG (CH) | 1979-02-07 | — | — | EP | claimed |
| EP-0000331-A1 | Method of mass-dyeing linear polyamides using dyesalts from 1:2 chromium complexes of monoazodyes; the fibres obtained therefrom | CIBA-GEIGY AG (CH) | 1979-01-24 | — | — | EP | claimed |
| EP-0000157-A1 | Process for the manufacture of highly concentrated aqueous solutions of salts of dicarboxylic acids with diamines and/of polyamide precondensates and their use | BASF Aktiengesellschaft (DE) | 1979-01-10 | — | — | EP | claimed |
| EP-0000174-A1 | Derivatives of aminobenzoic acids, process for their preparation and pharmaceutical compositions containing them. | Ludwig Merckle GmbH & Co. chem.-pharm. Fabrik (DE) | 1979-01-10 | — | — | EP | claimed |
| EP-0000142-A1 | Process for the preparation of polyamides | BASF Aktiengesellschaft (DE) | 1979-01-10 | — | — | EP | claimed |
| US-3970501-A | PRESSURE SENSITIVE, FORMALDEHYDE-NAPHTHALENESULFONIC ACID | FUJI PHOTO FILM CO., LTD. (JA) | 1976-07-20 | — | — | US | claimed |