Known targets — ChEMBL curated mechanism
COXFA4COXFA4L2GPD2MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3
The experimentally established mechanism targets of Metformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metformin SCHEMBL18953625 | 0.97 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL15268394 | 0.97 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL22977 | 0.97 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL19583451 | 0.97 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL4421557 | 0.97 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL433864 | 0.97 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL1547913 | 0.97 | HTT (0.39) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL28854120 | 0.95 | HTT (0.37) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL1714633 | 0.95 | HTT (0.37) | HTTLMNADPP4ADRA1A | |
| Metformin SCHEMBL1747396 | 0.95 | HTT (0.37) | HTTLMNADPP4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090308646-A1 | CONDUCTOR PATTERN FORMING INK, CONDUCTOR PATTERN, AND WIRING SUBSTRATE | SEIKO EPSON CORPORATION (JP) | 2009-12-17 | — | — | US | disclosed |