Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22988869 | 0.84 | MAP2K1 (0.40) | GRM8GRM4CAMKK2MAP2K1CNR2 | |
| SCHEMBL878759 | 0.80 | MET (0.42) | GRM8GRM4MAP2K1AXLBRD4 | |
| SCHEMBL21872984 | 0.79 | CDC7 (0.41) | GRM8GRM4CAMKK2MAP2K1CNR2 | |
| SCHEMBL1267952 | 0.79 | AXL (0.48) | GRM8GRM4CAMKK2MAP2K1KMT2A | |
| SCHEMBL22978453 | 0.79 | NPC1 (0.35) | — | |
| SCHEMBL857039 | 0.78 | MAPT (0.49) | GRM8GRM4CAMKK2MAP2K1KMT2A | |
| SCHEMBL1267562 | 0.78 | CDC7 (0.41) | GRM8GRM4CNR2BRD4MET | |
| SCHEMBL28467009 | 0.77 | MAP2K1 (0.43) | GRM8GRM4CAMKK2MAP2K1CNR2 | |
| SCHEMBL1268047 | 0.76 | CSF1R (0.50) | METMAPTCDC7MAP4K4DYRK1A | |
| SCHEMBL27975426 | 0.76 | CSF1R (0.48) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018233526-A9 | CSF1R INHIBITOR, AND MANUFACTURING METHOD THEREFOR AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2021-02-18 | — | — | WO | disclosed |