Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878781 | 0.85 | CSF1R (0.68) | CSF1RKITBRD4HTR2AHTR7 | |
| SCHEMBL22978447 | 0.76 | GRM8 (0.46) | BRD4 | |
| SCHEMBL857484 | 0.75 | CSF1R (0.70) | CSF1RKITHTR2AHTR7HTR6 | |
| SCHEMBL878759 | 0.74 | MET (0.42) | CSF1RKITBRD4 | |
| SCHEMBL1267952 | 0.74 | AXL (0.48) | BRD4 | |
| SCHEMBL21872984 | 0.74 | CDC7 (0.41) | BRD4 | |
| SCHEMBL28774095 | 0.74 | PTK6 (0.46) | — | |
| SCHEMBL1267463 | 0.73 | CSF1R (0.68) | CSF1RKITHTR2AHTR7HTR6 | |
| SCHEMBL1267798 | 0.73 | MAOB (0.45) | CSF1RKITBRD4 | |
| SCHEMBL1267562 | 0.73 | CDC7 (0.41) | CSF1RKITBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917235-A | Kinase modulation and indications therefor | PLEXXIKON INC | 2014-07-09 | — | — | CN | disclosed |