Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 8/20 | 0.38 |
| ▸ | DRD2 | P14416 | 6/20 | 0.38 |
| ▸ | DRD3 | P35462 | 6/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22988846 | 0.82 | CSF1R (0.45) | GPR84CYP3A4CYP2C19MTNR1ADRD4 | |
| SCHEMBL22978560 | 0.80 | GPR84 (0.41) | GPR84CYP3A4CYP2C19MTNR1ADRD4 | |
| SCHEMBL22988842 | 0.73 | GPR84 (0.49) | GPR84CYP3A4CYP2C19MTNR1AMET | |
| SCHEMBL22988865 | 0.70 | CSF1R (0.45) | CYP3A4CYP2C19MTNR1ACSF1RKIT | |
| SCHEMBL22988876 | 0.69 | CSF1R (0.46) | CYP3A4CYP2C19MTNR1ACSF1RKIT | |
| SCHEMBL22988862 | 0.69 | CSF1R (0.44) | CYP3A4CYP2C19MTNR1ACSF1RKIT | |
| SCHEMBL22988863 | 0.68 | KIT (0.45) | CYP3A4CYP2C19DRD3CSF1RKIT | |
| SCHEMBL21304797 | 0.68 | MET (0.60) | GPR84CYP3A4CYP2C19METNTRK1 | |
| SCHEMBL21873023 | 0.68 | GPR84 (0.66) | GPR84CYP3A4CYP2C19MTNR1ADRD4 | |
| SCHEMBL22978564 | 0.68 | GPR84 (0.66) | GPR84CYP3A4CYP2C19MTNR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018233526-A9 | CSF1R INHIBITOR, AND MANUFACTURING METHOD THEREFOR AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2021-02-18 | — | — | WO | disclosed |