Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30525604 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDPDE3AALDH1A1KDM4E | |
| SCHEMBL27525988 | 0.78 | HPGD (0.56) | SMN1; SMN2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL3432979 | 0.77 | MAPK1 (0.42) | SMN1; SMN2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL22978501 | 0.75 | HPGD (0.41) | SMN1; SMN2HPGDPDE3AALDH1A1KDM4E | |
| SCHEMBL9929711 | 0.74 | MEN1 (0.42) | SMN1; SMN2HPGDPDE3AALDH1A1KDM4E | |
| SCHEMBL12843986 | 0.73 | ALDH1A1 (0.50) | SMN1; SMN2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL9834103 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDPDE3AALDH1A1KDM4E | |
| SCHEMBL3076234 | 0.72 | SQOR (0.55) | SMN1; SMN2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL14592934 | 0.69 | ALDH1A1 (0.49) | SMN1; SMN2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL23087507 | 0.68 | PDE3A (0.43) | SMN1; SMN2HPGDPDE3AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026672-A1 | HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS | NOVARTIS AG (CH) | 2021-02-18 | — | — | WO | disclosed |