Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639279 | 0.84 | NOTUM (0.40) | MAPTLMNASMN1; SMN2NOTUMMEN1 | |
| SCHEMBL30626572 | 0.84 | NOTUM (0.40) | MAPTLMNASMN1; SMN2NOTUMMEN1 | |
| SCHEMBL2298161 | 0.83 | MAPT (0.42) | MAPTLMNASMN1; SMN2NOTUMMEN1 | |
| SCHEMBL27427307 | 0.83 | TAAR1 (0.50) | MAPTLMNASMN1; SMN2TDP1GAA | |
| SCHEMBL27789311 | 0.81 | NR3C2 (0.46) | NPSR1DAOEPHX1PTPN7DUSP3 | |
| SCHEMBL25090455 | 0.79 | IDO1 (0.57) | LMNANOTUMDAOIDO1 | |
| SCHEMBL30201341 | 0.79 | IDO1 (0.57) | LMNANOTUMDAOIDO1 | |
| SCHEMBL2089711 | 0.78 | NOTUM (0.39) | MAPTLMNASMN1; SMN2NOTUMMEN1 | |
| SCHEMBL2094824 | 0.78 | KIF11 (0.47) | MAPTLMNASMN1; SMN2NOTUMMEN1 | |
| SCHEMBL13429965 | 0.78 | NOTUM (0.39) | MAPTLMNASMN1; SMN2NOTUMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102666541-B | Purine or deazapurine derivatives for the treatment of, in particular, viral infections | GILEAD SCIENCES, INC. (US) | 2015-11-25 | — | — | CN | disclosed |
| CN-102666541-A | Purine or deazapurine derivatives for the treatment of, in particular, viral infections | GILEAD SCIENCES INC | 2012-09-12 | — | — | CN | disclosed |
| WO-2011103063-A1 | THERAPEUTIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-08-25 | — | — | WO | disclosed |