Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2094824 | 0.85 | KIF11 (0.47) | MAPTGAALMNASMN1; SMN2PDK2 | |
| SCHEMBL2298235 | 0.83 | MAPT (0.39) | MAPTGAALMNASMN1; SMN2MEN1 | |
| SCHEMBL27427307 | 0.81 | TAAR1 (0.50) | MAPTKDM4EALDH1A1GAALMNA | |
| SCHEMBL3637053 | 0.79 | NR3C2 (0.49) | MAPTKDM4EALDH1A1ALOX5GAA | |
| SCHEMBL6813477 | 0.79 | KDM4E (0.59) | MAPTKDM4EALDH1A1ALOX5GAA | |
| SCHEMBL1639279 | 0.79 | NOTUM (0.40) | MAPTGAALMNASMN1; SMN2MEN1 | |
| SCHEMBL30626572 | 0.79 | NOTUM (0.40) | MAPTGAALMNASMN1; SMN2MEN1 | |
| SCHEMBL5722021 | 0.78 | TRPV1 (0.58) | MAPTKDM4EALDH1A1ALOX5GAA | |
| SCHEMBL2089711 | 0.77 | NOTUM (0.39) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2089713 | 0.77 | LOXL2 (0.43) | MAPTLMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103063-A1 | THERAPEUTIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-08-25 | — | — | WO | disclosed |