Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300110 | 0.84 | KMT2A (0.41) | LMNANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL14152092 | 0.76 | THRB (0.52) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21381054 | 0.73 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2MAPTPOLBL3MBTL1 | |
| SCHEMBL15874475 | 0.72 | THRB (0.52) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2297057 | 0.72 | USP30 (0.50) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15874474 | 0.72 | THRB (0.52) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2298365 | 0.71 | THRB (0.44) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15064460 | 0.69 | HDAC3 (0.43) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15064582 | 0.69 | CNR2 (0.33) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2355152 | 0.69 | FASN (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103546-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-08-25 | — | — | WO | disclosed |