Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 9/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 9/20 | 0.49 |
| ▸ | ITGB7 | P26010 | 9/20 | 0.49 |
| ▸ | GRB2 | P62993 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22983179 | 1.00 | ITGB1 (0.49) | ITGB1ITGA4ITGB7GRB2SLC7A5 | |
| SCHEMBL22983622 | 0.91 | ITGB1 (0.49) | ITGB1ITGA4ITGB7GRB2SLC7A5 | |
| SCHEMBL23003302 | 0.91 | ITGB1 (0.49) | ITGB1ITGA4ITGB7GRB2SLC7A5 | |
| SCHEMBL22996662 | 0.89 | ITGB1 (0.45) | ITGB1ITGA4ITGB7PTGS2 | |
| SCHEMBL6297453 | 0.86 | ITGB1 (0.63) | ITGB1ITGA4ITGB7GRB2SLC7A5 | |
| SCHEMBL22982364 | 0.86 | ITGB1 (0.63) | ITGB1ITGA4ITGB7GRB2SLC7A5 | |
| SCHEMBL21979276 | 0.80 | ITGB1 (0.48) | ITGB1ITGA4ITGB7KDM4ERECQL | |
| SCHEMBL21979273 | 0.80 | ITGB1 (0.48) | ITGB1ITGA4ITGB7KDM4ERECQL | |
| SCHEMBL22996698 | 0.80 | ITGB1 (0.45) | ITGB1ITGA4ITGB7PTGS2 | |
| SCHEMBL22996661 | 0.77 | PDE3B (0.41) | ITGB1ITGA4ITGB7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11578069-B2 | Compounds for inhibition of α4 β7 integrin | GILEAD SCIENCES, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| EP-4013499-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. (US) | 2022-06-22 | — | — | EP | disclosed |
| CN-114222730-A | Compounds for inhibiting alpha 4 beta 7 integrins | 吉利德科学公司 | 2022-03-22 | — | — | CN | disclosed |
| US-20210053967-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. | 2021-02-25 | — | — | US | disclosed |
| WO-2021030438-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | GILEAD SCIENCES, INC. (US) | 2021-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11578069-B2 | Compounds for inhibition of α4 β7 integrin | ITGB7, ITGB4, ITGA4 | ITGB1 4/4885ITGA4 3/4885ITGB7 1/4885 |
| US-20210053967-A1 | COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN | ITGB7, ITGB4, ITGA4 | ITGB1 4/4885ITGA4 3/4885ITGB7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.