Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SLC8A1 | P32418 | 4/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22984363 | 0.93 | HTT (0.42) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL22984292 | 0.87 | HTT (0.47) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL22984269 | 0.85 | HTT (0.46) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL22984364 | 0.84 | CYP2C9 (0.36) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL16945294 | 0.79 | HTT (0.48) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL22984308 | 0.78 | HTT (0.44) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL22984280 | 0.78 | LMNA (0.44) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL22984265 | 0.78 | HTT (0.48) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL22984267 | 0.77 | HTT (0.47) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL22984263 | 0.77 | ALDH1A1 (0.48) | HTTSMN1; SMN2LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919888-B2 | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2021-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919888-B2 | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection | BET1, BRD4, BRD3 | HTT 4525/4885SMN1; SMN2 3362/4885LMNA 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.