Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FES | P07332 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | TTK | P33981 | 5/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.51 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.51 |
| ▸ | PLK4 | O00444 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | PI4KA | P42356 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.51 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.51 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.51 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.51 |
| ▸ | DCLK2 | Q8N568 | 1/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985900 | 0.93 | FES (0.74) | FESFLT3TTKDCLK1MAPK7 | |
| SCHEMBL3958582 | 0.86 | FES (0.87) | FESFLT3TTKDCLK1MAPK7 | |
| SCHEMBL22985905 | 0.84 | FES (0.64) | FESFLT3TTKPTK2IGF1R | |
| SCHEMBL22985878 | 0.84 | FES (0.61) | FESFLT3TTKDCLK1MAPK7 | |
| SCHEMBL22985890 | 0.83 | FES (0.60) | FESFLT3TTKDCLK1MAPK7 | |
| SCHEMBL21099489 | 0.83 | ALK (0.54) | FESFLT3TTKDCLK1MAPK7 | |
| SCHEMBL3959984 | 0.79 | FES (0.80) | FESFLT3TTKDCLK1MAPK7 | |
| SCHEMBL3954048 | 0.78 | FES (1.00) | FESFLT3TTKDCLK1MAPK7 | |
| SCHEMBL12780076 | 0.78 | ALK (0.64) | FESFLT3TTKDCLK1MAPK7 | |
| SCHEMBL3954360 | 0.78 | FES (0.86) | FESFLT3TTKDCLK1MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |