Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.47 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.47 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | DCLK2 | Q8N568 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 5/20 | 0.46 |
| ▸ | IGF1R | P08069 | 5/20 | 0.46 |
| ▸ | TTK | P33981 | 4/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099605 | 0.93 | ALK (0.62) | ALKPTK2INSRIGF1RTTK | |
| SCHEMBL21100183 | 0.92 | ALK (0.56) | ALKDCLK1PTK2MAPK7LRRK2 | |
| SCHEMBL21099501 | 0.92 | ALK (0.52) | ALKPTK2TNK2INSRIGF1R | |
| SCHEMBL21099488 | 0.86 | ALK (0.73) | ALKPLK4DCLK1RPS6KA3PTK2 | |
| SCHEMBL21100193 | 0.85 | IRAK4 (0.59) | ALKBRD4LRRK2PLK1IRAK4 | |
| SCHEMBL21099658 | 0.84 | ALK (0.60) | ALKPLK4DCLK1RPS6KA3PTK2 | |
| SCHEMBL21099499 | 0.84 | ALK (0.75) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL21099498 | 0.84 | ALK (0.60) | ALKPLK4DCLK1RPS6KA3PTK2 | |
| SCHEMBL21099810 | 0.84 | IRAK4 (0.46) | ALKTTKPLK1IRAK4EGFR | |
| SCHEMBL21099502 | 0.83 | ALK (0.59) | ALKPLK4DCLK1RPS6KA3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |