Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 5/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | PHF20 | Q9BVI0 | 1/20 | 0.40 |
| ▸ | MORF4L1 | Q9UBU8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985881 | 0.90 | MAPK7 (0.53) | MAPK7LRRK2BRD4BRDTDCLK1 | |
| SCHEMBL18018898 | 0.76 | MAPK7 (0.48) | MAPK7LRRK2BRD4BRDTDCLK1 | |
| SCHEMBL22985860 | 0.75 | LRRK2 (0.53) | MAPK7LRRK2BRD4BRDTDCLK1 | |
| SCHEMBL4052463 | 0.75 | ALK (0.48) | MAPK7LRRK2 | |
| SCHEMBL4048691 | 0.74 | ALK (0.55) | MAPK7LRRK2DCLK1KCNH2 | |
| SCHEMBL18018896 | 0.70 | ALK (0.53) | MAPK7LRRK2BRD4BRDTDCLK1 | |
| SCHEMBL19921183 | 0.70 | LRRK2 (0.54) | MAPK7LRRK2BRD4BRDTDCLK1 | |
| SCHEMBL22985912 | 0.70 | LRRK2 (0.72) | LRRK2 | |
| SCHEMBL4047900 | 0.69 | FES (0.66) | MAPK7LRRK2DCLK1KCNH2 | |
| SCHEMBL18018798 | 0.69 | TTK (0.54) | MAPK7LRRK2BRD4BRDTDCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |