Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.53 |
| ▸ | HTR7 | P34969 | 4/20 | 0.45 |
| ▸ | BUB1 | O43683 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295783 | 0.75 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL5353409 | 0.74 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11HTR7 | |
| SCHEMBL6508399 | 0.73 | MEN1 (0.38) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL7214775 | 0.69 | NR3C2 (0.57) | MAPK14MAPK13MAPK12MAPK11HTR7 | |
| SCHEMBL2896073 | 0.69 | MAPK14 (0.93) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2849513 | 0.68 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11HTR7 | |
| SCHEMBL828375 | 0.68 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11BUB1 | |
| SCHEMBL2846548 | 0.67 | MAPK14 (0.82) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL11099101 | 0.66 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11HTR7 | |
| SCHEMBL4257781 | 0.66 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011100769-A2 | KINASE MODULATORS FOR THE TREATMENT OF CANCER | SYNOVO GMBH (DE) | 2011-08-18 | — | — | WO | disclosed |