Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298492 | 0.78 | DPP4 (0.38) | — | |
| SCHEMBL2298520 | 0.78 | DPP4 (0.35) | — | |
| SCHEMBL2297645 | 0.77 | DPP4 (0.41) | — | |
| SCHEMBL2302363 | 0.75 | DPP4 (0.30) | — | |
| SCHEMBL2299117 | 0.68 | — | — | |
| SCHEMBL1487982 | 0.66 | ATM (0.42) | ATMLTA4HTDP1TSHRALDH1A1 | |
| SCHEMBL31276553 | 0.66 | TSHR (0.38) | ATMLTA4HTDP1TSHRALDH1A1 | |
| SCHEMBL20940045 | 0.65 | ATM (0.41) | ATMLTA4HTDP1TSHRALDH1A1 | |
| SCHEMBL1487980 | 0.65 | ATM (0.41) | ATMLTA4HTDP1TSHRALDH1A1 | |
| SCHEMBL14817919 | 0.65 | TSHR (0.42) | ATMLTA4HTDP1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |