Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 4/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18704846 | 0.77 | HTR2A (0.35) | EIF2AK4HTR2AHTR2CHTR2BIDH1 | |
| SCHEMBL21503651 | 0.76 | PRMT6 (0.34) | EIF2AK4HTR2AHTR2CHTR2BIDH1 | |
| SCHEMBL31390069 | 0.76 | HTR2A (0.34) | EIF2AK4HTR2AHTR2CHTR2BIDH1 | |
| SCHEMBL21503406 | 0.76 | PRMT6 (0.34) | EIF2AK4HTR2AHTR2CHTR2BIDH1 | |
| Hydrochloric Acid SCHEMBL21492706 | 0.75 | PRMT6 (0.33) | EIF2AK4HTR2AHTR2CHTR2BIDH1 | |
| Hydrochloric Acid SCHEMBL21492708 | 0.75 | PRMT6 (0.33) | EIF2AK4HTR2AHTR2CHTR2BIDH1 | |
| SCHEMBL26744414 | 0.75 | FAAH (0.45) | EIF2AK4HTR2AHTR2CHTR2BIDH1 | |
| SCHEMBL28858399 | 0.75 | IDH1 (0.35) | EIF2AK4HTR2AHTR2CHTR2BIDH1 | |
| SCHEMBL743741 | 0.75 | IDH1 (0.35) | EIF2AK4HTR2AHTR2CHTR2BIDH1 | |
| SCHEMBL744035 | 0.73 | IDH1 (0.34) | EIF2AK4HTR2AHTR2CHTR2BIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021027943-A1 | PYRIMIDINOPYRIDAZINONE DERIVATIVE AND MEDICAL USE THEREOF | 正大天晴药业集团南京顺欣制药有限公司 | 2021-02-18 | — | — | WO | disclosed |