Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TAF1 | P21675 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22981490 | 0.77 | CYP2C9 (0.37) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL25344358 | 0.74 | BRD9 (0.37) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL26831959 | 0.73 | BRD4 (0.34) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL2594416 | 0.73 | BRD9 (0.39) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL29911927 | 0.71 | BRD9 (0.38) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL29565072 | 0.71 | SCD (0.35) | GAA | |
| SCHEMBL19785547 | 0.69 | BRD9 (0.37) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL31439950 | 0.69 | ATAD2 (0.39) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL29565022 | 0.69 | NOTUM (0.32) | BRD4 | |
| SCHEMBL1076952 | 0.68 | GRM2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010334-A1 | HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS | Novartis AG (CH) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021026672-A1 | HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS | NOVARTIS AG (CH) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028806-A1 | HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS | NOVARTIS AG (CH) | 2021-02-18 | — | — | WO | disclosed |
| CN-108558889-A | Bu Luomo structural domain inhibitor | 赛尔基因昆蒂赛尔研究公司 | 2018-09-21 | — | — | CN | disclosed |
| CN-108137539-A | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | 尼奥迈德研究所 | 2018-06-08 | — | — | CN | disclosed |