SCHEMBL22992196

SCHEMBL22992196

CC#Cc1cc(C)c(C2C(=O)CC3(CCN(C(=O)NC4CCCC4)CC3)CC2=O)c(C)c1

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.38
LMNA P02545 3/20 0.37
MAPT P10636 2/20 0.37
USP2 O75604 1/20 0.37
HTT P42858 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
KDM4E B2RXH2 2/20 0.36
P2RX7 Q99572 1/20 0.36
TP53 P04637 1/20 0.35
ALDH1A1 P00352 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
EPHX2 P34913 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22992166 0.96 EPHX2 (0.36) RAB9ALMNAMAPTUSP2HTT
SCHEMBL24324820 0.89 FASN (0.32) LMNAKDM4EALDH1A1
SCHEMBL22992125 0.87 CYP2D6 (0.33) USP2ALDH1A1SMN1; SMN2
SCHEMBL22992095 0.87 PIK3CA (0.34)
SCHEMBL24324818 0.86 GRIN1 (0.31)
SCHEMBL21343729 0.86 CYP3A4 (0.42) USP2ALDH1A1SMN1; SMN2
SCHEMBL21344248 0.85 HIF1A (0.32)
SCHEMBL21344271 0.84
SCHEMBL24426488 0.84 HIF1A (0.30)
SCHEMBL22992121 0.84 KMT2A (0.36) HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12043599-B2 Herbicidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2024-07-23 US disclosed
EP-3762378-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2022-05-18 EP disclosed
US-20210047274-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-02-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210047274-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 RAB9A 1979/4885LMNA 4259/4885MAPT 3999/4885
US-12043599-B2 Herbicidal compounds DDT, CBR3, GLRX3 RAB9A 1979/4885LMNA 4259/4885MAPT 3999/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.