SCHEMBL22992263

SCHEMBL22992263

CC#Cc1cc(C)c(C2C(=O)CC3(CCN(C(=O)C(C)OC(F)F)CC3)CC2=O)c(C)c1

nearest known ligand 0.30

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30
ALOX12 P18054 1/20 0.30
HTT P42858 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21343913 0.92 LMNA (0.31) LMNAMAPTALOX12HTTSMN1; SMN2
SCHEMBL21344686 0.89 LMNA (0.31) LMNAMAPTALOX12HTTSMN1; SMN2
SCHEMBL21344678 0.89 LMNA (0.31) LMNAMAPTALOX12HTTSMN1; SMN2
SCHEMBL22992230 0.89 LMNA (0.31) LMNAMAPTALOX12HTTSMN1; SMN2
SCHEMBL21285231 0.89 BTK (0.30)
SCHEMBL21285145 0.88 BTK (0.30)
SCHEMBL21343906 0.88 LMNA (0.33) LMNAMAPTALOX12HTTSMN1; SMN2
SCHEMBL21344737 0.87
SCHEMBL21344689 0.87
SCHEMBL21344688 0.87

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12043599-B2 Herbicidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2024-07-23 US disclosed
US-12043599-B2 Herbicidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2024-07-23 US disclosed
EP-3762378-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2022-05-18 EP disclosed
US-20210047274-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-02-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210047274-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 LMNA 4259/4885MAPT 3999/4885ALOX12 2032/4885
US-12043599-B2 Herbicidal compounds DDT, CBR3, GLRX3 LMNA 4259/4885MAPT 3999/4885ALOX12 2032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.