Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3440774 | 0.88 | MAOA (0.43) | MAOAMAOBKDM4ECHRNA7CYP1A2 | |
| SCHEMBL24762543 | 0.84 | SLC6A2 (0.42) | SLC6A2SLC6A3 | |
| SCHEMBL8184550 | 0.80 | CYP2C19 (0.38) | SLC6A2SLC6A3MAOAMAOBKDM4E | |
| SCHEMBL13184287 | 0.78 | ADRA2A (0.53) | CYP2D6ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL24253238 | 0.77 | ADRA2A (0.40) | MAOAMAOBKDM4ENOTUMADRA2A | |
| SCHEMBL24253218 | 0.77 | KDM4E (0.36) | SLC6A2MAOAMAOBKDM4ECHRNA7 | |
| SCHEMBL12853675 | 0.77 | SLC6A2 (0.37) | SLC6A2SLC6A3MAOAMAOBNOTUM | |
| SCHEMBL21195922 | 0.76 | MAOA (0.48) | MAOAMAOBCYP1A2CYP2D6NOTUM | |
| SCHEMBL13184293 | 0.74 | ADRA2A (0.53) | CYP2D6ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL17815299 | 0.74 | MAOA (0.49) | MAOAMAOBKDM4ENOTUMDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |