Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 11/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22993231 | 0.90 | F11 (0.40) | F11KLKB1ROCK2CYP3A4 | |
| SCHEMBL22993470 | 0.83 | KLKB1 (0.57) | F11KLKB1ROCK2CYP3A4 | |
| SCHEMBL22993392 | 0.83 | KLKB1 (0.67) | F11KLKB1ROCK2CYP3A4 | |
| SCHEMBL22993477 | 0.80 | F11 (0.70) | F11KLKB1 | |
| SCHEMBL29405892 | 0.80 | KLKB1 (0.73) | F11KLKB1 | |
| SCHEMBL22993228 | 0.80 | KLKB1 (0.73) | F11KLKB1 | |
| SCHEMBL22993335 | 0.75 | SMN1; SMN2 (0.47) | F11KLKB1ROCK2CYP3A4 | |
| SCHEMBL22993383 | 0.73 | F11 (0.69) | F11KLKB1 | |
| SCHEMBL22981945 | 0.73 | KLKB1 (0.65) | F11KLKB1 | |
| SCHEMBL22993229 | 0.71 | KLKB1 (0.61) | F11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |