Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 10/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22993230 | 0.90 | F11 (0.47) | F11KLKB1ROCK2CYP3A4 | |
| SCHEMBL22993229 | 0.82 | KLKB1 (0.61) | F11KLKB1 | |
| SCHEMBL29388690 | 0.82 | KLKB1 (0.61) | F11KLKB1 | |
| SCHEMBL22993102 | 0.77 | F11 (0.57) | F11KLKB1 | |
| SCHEMBL29390120 | 0.75 | NR1H2 (0.53) | NR1H2 | |
| SCHEMBL22982263 | 0.75 | NR1H2 (0.53) | NR1H2 | |
| SCHEMBL22993392 | 0.75 | KLKB1 (0.67) | F11KLKB1ROCK2CYP3A4 | |
| SCHEMBL22993470 | 0.74 | KLKB1 (0.57) | F11KLKB1ROCK2CYP3A4 | |
| SCHEMBL22981212 | 0.74 | NR1H2 (0.54) | NR1H2 | |
| SCHEMBL29388827 | 0.74 | NR1H2 (0.54) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |