⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253235 | 0.82 | CCNT1 (0.30) | — | |
| SCHEMBL24253254 | 0.78 | — | — | |
| SCHEMBL22993428 | 0.72 | — | — | |
| SCHEMBL26928424 | 0.62 | CYP2C19 (0.33) | — | |
| SCHEMBL28627037 | 0.60 | POLB (0.38) | — | |
| SCHEMBL21947385 | 0.56 | KDM4E (0.41) | — | |
| SCHEMBL31710900 | 0.55 | MPO (0.40) | — | |
| SCHEMBL15832226 | 0.54 | SIGMAR1 (0.43) | — | |
| SCHEMBL21597663 | 0.53 | PIK3CA (0.41) | — | |
| SCHEMBL18161176 | 0.53 | KCNJ6 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |